Ji, Bingyuan, Shang, Liyan, Wang, Chunmei, Wan, Lei, Cheng, Baohua, Chen, Jing, 2020. Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis. Yin, Haiyan, Zhang, Hui, Kong, Youhua, Wang, Chunmei, Guo, Yan, Gao, Yang, Yuan, Lili, Yang, Xinxin, Chen, Jing, 2020. Biochemical and Biophysical Research Communications, 521 (2), pp. Transmembrane peptide 4 and 5 of APJ are essential for its heterodimerization with OX1R. Wan, Lei, Xu, Fangfang, Liu, Chang, Ji, Bingyuan, Zhang, Rumin, Wang, Peixiang, Wu, Fei, Pan, Yanyou, Yang, Chunqing, Wang, Chunmei, Chen, Jing, 2020. Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction. Chen, Jing, Chen, Xiaoyu, Li, Sheng, Jiang, Yunlu, Mao, Huiling, Zhang, Rumin, Ji, Bingyuan, Yan, Maocai, Cai, Xin, Wang, Chunmei, 2020. A novel phosphorylation site on orexin receptor 1 regulating orexinA-induced GRK2-biased signaling. Cai, Xin, Wang, Huannan, Wang, Maochang, Wang, Dexiu, Zhang, Zhen, Wei, Ruotong, Gao, Xiang, Zhang, Rumin, Wang, Chunmei, Chen, Jing, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1868 (1) A method for identifying G protein-coupled receptor dimers and their interfaces. Chen, Jing, Cai, Xin, Yan, Maocai, Wang, Zhengwen, Lv, Zhitong, Wang, Chunmei, 2021. Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway. Xu, Dandan, Kong, Tingting, Zhang, Shengnan, Cheng, Baohua, Chen, Jing, Wang, Chunmei, 2021. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. 2015 Dec 7(12):968-79.Ħ-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.Ħ-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth. 
Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. ?-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation. University of Science and Technology of China Two major research focuses include (1) To determine both metabolic and signaling functions of intracellular metabolites and circulating “blood chemicals”, which influence tumorigenesis and tumor progression, and responses to anti-cancer therapies including chemotherapy and immunotherapy and (2) To decipher mechanistic basis underlying the pathogenic links between diets and particular oncogenic mutations by exploring the pro- and anti-tumor effects of diet-derived substances on tumors with specific genetic backgrounds. Chen is interested in elucidating the signaling interplay between metabolic and cell signaling networks for a better understanding of cancer metabolism and improved clinical outcome.
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